"Cats and dogs must set aside their differences and merge animal instincts when Kitty Galore (voice of Bette Midler), a nefarious feline with a Cleopatra complex, decides to claw her way to global domination in this sequel to 2001's Cats & Dogs. It's spy vs. spy as Butch, Peek and their calico crew attempt to foil Kitty's hair-raising high jinks while bumbling human companions Shane (Chris O'Donnell) and Chuck (Jack McBrayer) get underfoot."