Bud and Doyle are two losers who are doing nothing with their lives. Both of their girlfriends are actively involved in saving the environment, but the two friends couldn't care less about saving the Earth. One day, when a group of scientists begin a mission to live inside a "Bio-Dome" for a year without outside contact, Bud and Doyle mistakenly become part of the project themselves.
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|Pauly Shore||Bud Macintosh|
|Stephen Baldwin||Doyle Johnson|
|Joey Lauren Adams||Monique (as Joey Adams)|
|William Atherton||Dr. Noah Faulkner|
|Dara Tomanovich||Mimi Simkins|
|Kevin West||T.C. Romulus|
|Denise Dowse||Olivia Biggs|
|Kylie Minogue||Dr. Petra von Kant|
|Kyle Gass||Tenacious D|
|Jack Black||Tenacious D|
|Phedon Papamichael||Director of Photography||